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刘见永

日期：2021-11-01 阅读次数：作者：来源：

	姓名：	刘见永
	性别：	男
	职称：	研究员（博导）
	学历：	博士
	职务：
	电话：	0591-22867105
	专业：	有机化学、药物化学、药理学、制药工程
	电子邮件：	liujianyong82@163.com
	研究方向：	有机共轭大环化合物的合成及性能研究

教育工作经历

2011 - 至今 betway唯一官方网站副研究员、研究员

2008－2010 香港中文大学化学系博士后

2005－2008 香港中文大学化学系博士

教学简介

承担本科生课程：《有机化学》《综合化学实验》《有机化学实验》

承担研究生课程：《实验室安全讲座》《有机化学研究方法与实验》

科研简介

研究兴趣：

氟硼二吡咯、酞菁类抗癌光敏药物的设计与药效研究；

有机染料分子荧光探针的设计及其在细胞、活体肿瘤中的成像研究；

染料敏化太阳能电池材料的设计及其光电转换性能研究；

酞菁和氟硼二吡咯的超分子化学。

社会兼职

中国抗癌协会光动力治疗专业委员会委员

中国化学会应用化学学科委员会卟啉与酞菁专业委员会秘书

担任Chemical Communications, Journal of Medicinal Chemistry, Green Chemistry, Chemistry A European Journal, Organic Letters, RSC Advances, ChemMedChem, Current Medicinal Chemistry等期刊的通讯审稿人。

科研项目

1. 国家自然科学基金：生物素介导靶向光动力治疗-化疗联用抗癌药物的合成及构效关系研究 (No.21401733)

2. 国家自然科学基金：叶酸-酞菁共轭物抗癌光敏剂的合成及其靶向光动力活性 (No.21101028)

3. 福建省科技厅重大项目：抗癌光敏剂福大赛因临床 2期人体药代动力学研究 (No. 2015Y0086)

4. 福建省自然科学基金：光动力治疗-化疗联用前药的合成及协同抗肿瘤活性研究 (No. 2020J01440)

5. 福建省自然科学基金：Cu（I）催化“点击化学”合成靶向抗癌光敏剂 (No.2012J05021)

6. betway必威西汉姆联官网海外引进人才项目：功能配合物 (No.6022382)

7. betway必威西汉姆联官网科研启动项目：靶向抗癌光敏剂的研究 (No.600366)

8. betway必威西汉姆联官网科技发展基金：分子靶点抗癌光敏剂 (N0.2011-XY-6)

代表性论文

1. Wang, S.; Fu, Q.; Su, L.; Wu, Y.; Zhu, K.; Yang, D.-C.; Yang, X.-Z.; Weng, X.-L.; Liu, J.-Y.*; Song, J.* “Self-Reporting Molecular Prodrug for In Situ Quantitative Sensing of Drug Release by Ratiometric Photoacoustic Imaging”, ACS Sensors, 2023, 8, 4737-4746.

2. Yang, X.-Z.; Wen, L.-F.; Xu, G.; Lin, H.-H.; Wang, S.; Liu, J.-Y.* “Multifunctional organic nanomaterials with ultra-high photothermal conversion efficiency for photothermal therapy and inhibition of cancer metastasis”, Bioorganic Chemistry, 2023, 130, 106220.

3. Ke, Y.; Wei, D.; Lu, Z.; Cao, J.; Liu, J.-Y.; Fu, N. “A smart probe for multi-analyte signaling: Cascade detection of HSA mediated by N₂H₄”, Sensors and Actuators: B. Chemical, 2023, 395, 134456.

4. Yang, D.-C.; Wen, L.-F.; Du, L.; Luo, C.-M.; Lu, Z.-Y.; Liu, J.-Y.*; Lin, Z.* “A Hypoxia-Activated Prodrug Conjugated with a BODIPY-Based Photothermal Agent for Imaging-Guided Chemo-Photothermal Combination Therapy” ACS Applied Materials & Interfaces, 2022, 14, 40546-40558.

5. Yang, D.-C.; Yang, X.-Z.; Luo, C.-M.; Wen, L.-F.; Liu, J.-Y.*; Lin, Z.* “A promising strategy for synergistic cancer therapy by integrating a photosensitizer into a hypoxia-activated prodrug” Eur. J. Med. Chem., 2022, 243, 114749.

6. Zhang, H.-X.; Lin, H.-H.; Su, D.; Yang, D.-C.; Liu, J.-Y.* “Enzyme-Activated Multifunctional Prodrug Combining Site-Specific Chemotherapy with Light-Triggered Photodynamic Therapy”, Molecular Pharmaceutics 2022, 19, 630-641.

7. Hu, P.; Weng, X.-L.; Zhu, C.-H.; Yang, D.-C.; Liu, J.-Y.*; Chen, Z.*; Huang, M.* “Mitochondria-Targeting Boron Dipyrromethene Based Photosensitizers for Enhanced Photodynamic Therapy: Synthesis, Optical Properties, and in vitro Biological Activity”, ChemPlusChem, 2022, 87, e202200158.

8. Hu, P.; Xu, G.; Yang, D.-C.; Liu, J.-Y.*; Chen, Z.*; Huang, M.* “An advanced multifunctional prodrug combining photodynamic therapy with chemotherapy for highly efficient and precise tumor ablation”, Dyes and Pigments, 2022, 205, 110500.

9. Lin, H.-H.; Yang, X.-Z.; Yu, M.-Y.; Liu, J.-Y.* “A switchable phototherapeutic strategy based on a hypoxia-responsive photosensitizer for heterogeneous tumor ablation”, Dyes and Pigments, 2022, 201, 110217.

10. Lu, Z.; Xu, G.; Yang, X.; Liu, S.; Sun, Y.; Chen, L.; Liu, Q.; Liu, J.-Y.* “Dual-Activated Nano-Prodrug for Chemo-Photodynamic Combination Therapy of Breast Cancer” International Journal of Molecular Sciences, 2022, 23, 15656.

11. Xu, G.; Zhang, H.-X.; Li, X.-Q.; Yang, D.-C.; Liu, J.-Y.* “Red light triggered photodynamic-chemo combination therapy using a prodrug caged by photosensitizer”, Eur. J. Med. Chem., 2021, 215, 113251. DOI: 10.1016/j.ejmech.2021.113251.

12. Weng, X.-L.; Liu, J.-Y.* “Strategies for maximizing photothermal conversion efficiency based on organic dyes”, Drug Discov. Today, 2021, 26, 2045-2052. DOI: 10.1016/j.drudis.2021.03.009.

13. Yang, D.-C.; Wang, S.; Weng, X.-L.; Zhang, H.-X.; Liu, J.-Y.*; Lin, Z.* “Singlet Oxygen-Responsive Polymeric Nanomedicine for Light-Controlled Drug Release and Image-Guided Photodynamic−Chemo Combination Therapy”, ACS Appl. Mater. Interfaces, 2021, 13, 33905-33914.

14. Song, M.; Liu, G.; Liu, Y.; Cheng, Z.; Lin, H.; Liu, J.-Y.; Wu, Z.; Xue, J.; Hong, W.; Huang, M.; Li, J.; Xu, P. “Using porphyrins as albumin-binding molecules to enhance antitumorefficacies and reduce systemic toxicities of antimicrobial peptides”, Eur. J. Med. Chem., 2021, 217, 113382. DOI: 10.1016/j.ejmech.2021.113382.

15. Cao, J.-J.; Zhang, M.-S.; Li, X.-Q.; Yang, D.-C.; Xu, G.; Liu, J.-Y.* “A glutathione-responsive photosensitizer with fluorescence resonance energy transfer characteristics for imaging-guided targeting photodynamic therapy”. Eur. J. Med. Chem., 2020, 193, 112203. DOI:10.1016/j.ejmech.2020.112203.

16. Dai, T.; Ye, F.-R; Hu, P.; Pan, X.; Su, J.; Huang, Y.; Chen, J.; Zhang, L.; Wang, H.; Huang, M.; Liu, J.-Y.; Chen, X.; Chen, Z.*, “A strategy for enhanced tumor targeting of photodynamic therapy based on Escherichia coli-driven drug delivery system” Sci. China Mater., 2020, 64, 232-240.

17. Jiang, L.; Liu, Y.; Xu, X.; Su, D.; Zou, H.; Liu, J.-Y.; Yuan, C.; Huang, M. “Inhibition of the Citrus Canker Pathogen Using a Photosensitizer Assisted by Sunlight Irradiation”, Front Microbiol, 2020, 11, 571691.

18. Shi, W.-J.; Liu, J.-Y.; Lo, P.-C.; Ng, D. K.-P.* “Selective Detection of Hg²⁺ Ions with Boron Dipyrromethene-Based Fluorescent Probes Appended with a Bis(1,2,3-triazole)amino Receptor”, Chem. Asian. J., 2019, 14(7), 1059-1065.

19. Wang, Z.-W.; Su. D.; Li, X.-Q.; Cao, J.-J.; De-Chao Yang, Liu, J.-Y.* “A H₂O₂-Responsive Boron Dipyrromethene-Based Photosensitizer for Imaging-Guided Photodynamic Therapy”, Molecules 2019, 24, 32.

20. Chen, Y.; Liu, J.; Song, M.; Jiang, L.; Liu, L; Liu, Y.; Fu, G.; Xue, J.; Liu, J.-Y.*; Huang, M.*; Li, J*. “Insights into the binding mechanism of BODIPY-based photosensitizers to human serum albumin: A combined experimental and computational study”, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2018, 203, 158–165.

21. Lin, H.; Chen, J.; Zhang, Y.; Ullab, A.; Liu, J.-Y.; Lin, F.; Jiang, L.; Huang, M*. “Enhanced anti-microbial effect through cationization of a mono-triazatricyclodecane substituted asymmetric phthalocyanine”, J. Inorg. Biochem., 2018, 189, 192–198.

22. Zhang, F.-L.; Song, M.-R.; Yuan, G.-K.; Ye, H.-N.; Tian, Y.; Huang, M.-D.; Xue, J.-P.; Zhang, Z.-H.*; Liu, J.-Y.* “A Molecular Combo of Zinc(II) Phthalocyanine and Tamoxifen Derivative for Dual Targeting Photodynamic Therapy and Hormone Therapy” J. Med. Chem., 2017, 60, 6693-6703.

23. Liu, J.-Y.*; Hou, X.-N.; Tian, Y.; Jiang, L.*; Deng, S.; Röder, B.; Ermilov, E. A.* “Photoinduced energy and charge transfer in a bis(triphenylamine)–BODIPY–C₆₀ artificial photosynthetic system”, RSC Advances, 2016, 6, 57293-57305.

24. Liu, J.-Y.; Li, J.; Yuan, X.; Wang, W.-M.; Xue, J.-P.* “In vitro photodynamic activities of zinc(II) phthalocyanines substituted with pyridine moieties”, Photodiagnosis and Photodynamic Therapy, 2016, 13, 341-343.

25. Chen, J.; Ye, H.; Zhang, M.; Li, J.; Liu, J.-Y.*; Xue, J.-P.* “Erlotinib Analogue-substituted Zinc(II) Phthalocyanines for Small Molecular Target-based Photodynamic Cancer Therapy”, Chin. J. Chem., 2016, 34, 983-988.

26. Ermilov, E. A. *; Liu, J.-Y.; Menting, R.; Huang, Y.-S.; Röder, B.; Ng, D. K. P.* “An artificial photosynthetic model based on a molecular triad of boron dipyrromethene and phthalocyanine” Phys. Chem. Chem. Phys., 2016, 18, 10964-10975.

27. Zhang, F.-L.; Huang, Q.; Liu, J.-Y.; Huang, M.-D.; Xue, J.-P.* “Molecular-Target-Based Anticancer Photosensitizer: Synthesis and in vitro Photodynamic Activity of Erlotinib–Zinc(II)Phthalocyanine Conjugates” ChemMedChem, 2015, 10(2), 312-320.

28. Ermilov, E. A.*; Schlak, M.; Steffen, R.; Liu, X.-Q.; Liu, J.-Y.; Röder, B. “Energy transfer properties of a novel boron dipyrromethene–perylenediimide donor–acceptor dyad” RSC Adv., 2015, 5, 67141-67148.

29. Zhou, X.-Q.; Meng, L.-B.; Huang, Q.; Li, J.; Zheng, K.; Zhang, F.-L.; Liu, J.-Y.; Xue, J.-P.* “Synthesis and in vitro Anticancer Activity of Zinc(II) Phthalocyanines Conjugated with Coumarin Derivatives for Dual Photodynamic and Chemotherapy” ChemMedChem, 2015, 10, 304-311.

30. Lin, J.; Zhu, C.; Liu, X.; Chen, B.; Zhang, Y.; Xue, J.; Liu, J.-Y.* “A Highly Selective and turn-on fluorescence probe for Fe³⁺ ion based on perylene tetracarboxylic diimide” Chin. J. Chem., 2014, 32, 1116-1120.

31. Jia, X.; Yue, F.; Chen, X.; Pan, H.-B.; Liu, W.-G.*; Liu, J.-Y.* “One-pot controlled synthesis of single-crystal a-Fe₂O₃ hollow nanostructure and its gas sensing properties” RSC Adv., 2014, 4, 42899-42904.

32. Chen, Z.; Xu, P.; Chen, J.; Chen, H.; Hu, P.; Chen, X.; Lin, L.; Huang, Y.; Zheng, K.; Zhou, S.; Li, R.; Chen, S.; Liu, J.-Y.; Xue, J.; Huang, M. “Zinc phthalocyanine conjugated with the amino-terminal fragment of urokinase for tumor-targeting photodynamic therapy” Acta Biomaterialia, 2014, 10(10), 4257-4268.

33. Liu, J.-Y.; Huang, Y.-S.; Menting, R.; Röder, B.; Ermilov, E. A.; Ng, D. K. P.* “A boron dipyrromethene-phthalocyanine pentad as an artificial photosynthetic model” Chem. Commun. 2013, 49, 2998-3000.

34. Liu, J.-Y.; Ermilov, E. A.; Röder, B.; Ng, D. K. P.* “A light-harvesting porphyrin-boron dipyrromethene conjugate” J. Porphyrins Phthalocyanines 2013, 17, 831-835.

35. Menting, R.; Liu, J.-Y.; Huang, Y.-S.; Ng, D. K. P.; Röder, B.; Ermilov, E. A.* “Photoinduced energy and charge transfer in a p-phenylene-linked dyad of boron dipyrromethene and monostyryl boron dipyrromethene” Phys. Chem. Chem. Phys. 2013, 15, 6912-6919.

36. Zhang, F.-L.; Huang, Q.; Zheng, K.; Li, J.; Liu, J.-Y.*; Xue, J.-P.* “A novel strategy for targeting photodynamic therapy. Molecular combo of photodynamic agent zinc(II) phthalocyanine and small molecule target-based anticancer drug erlotinib” Chem. Commun. 2013, 49, 9570-9572.

37. Jia, X.; Yang, F.-F.; Li, J.; Liu, J.-Y.; Xue, J.-P.* “Synthesis and in Vitro Photodynamic Activity of Oligomeric Ethylene Glycol−Quinoline Substituted Zinc(II) Phthalocyanine Derivatives” J. Med. Chem. 2013, 56, 5797-5805.

38. He, H.; Liu, J.-Y.; and Ng, D. K. P.* “A Phthalocyanine-Based Fluorescent Sensor for Zn²⁺ Ion”, J. Porphyrins Phthalocyanines” 2013, 17, 99-103.

39. Liu, J.-Y.; El-Khouly, M. E.; Fukuzumi, S.; Ng, D. K. P.* “Photoinduced Electron Transfer in a Ferrocene-Distyryl BODIPY Dyad and a Ferrocene-Distyryl BODIPY-C₆₀ Triad” ChemPhysChem, 2012, 13, 2030-2036.

40. Shi, W.-J.; Liu, J.-Y.; Ng, D. K. P.* “A Highly Selective Colorimetric and Fluorescent Probe for Cu²⁺ and Hg²⁺ Ions Based on a Distyryl BODIPY with Two Bis(1,2,3-triazole)amino Receptors” Chem. Asian. J. 2012, 7(1), 196-200.

41. Liu, J.-Y.; El-Khouly, M. E.; Fukuzumi, S.*; Ng, D. K. P.* “Mimicking the Photosynthetic Antenna-Reaction Center Complexes with a (Boron Dipyrromethene)₃-Porphyrin-C₆₀ Pentad” Chem. Eur. J. 2011, 17, 1605-1613.

42. Liu, J.-Y.; El-Khouly, M. E.; Fukuzumi, S.; Ng, D. K. P.* “Photoinduced Electron Transfer in a Distyryl BODIPY-Fullerene Dyad” Chem. Asian. J. 2011, 6, 174-179.

43. Liu, J.-Y.; Lo, P.-C.; Ng, D. K. P.* “Phthalocyanine-Containing Supramolecular Arrays” Struct. Bond. 2010, 135, 169-210.

44. Liu, J.-Y.; Ermilov, E. A.; Röder, B.; Ng, D. K. P.* “Switching the photo-induced energy and electron-transfer processes in BODIPY-phthalocyanine conjugates” Chem. Commun. 2009, 45, 1517-1519.

45. Liu, J.-Y.; Lo, P.-C.; Jiang, X.-J.; Fong, W.-P.; Ng, D. K. P.* “Synthesis and in vitro photodynamic activities of di-a-substituted zinc(II) phthalocyanine derivatives” Dalton Trans. 2009, 38, 4129-4135.

46. Liu, J.-Y.; Lo, P.-C.; Fong, W.-P.; Ng, D. K. P.* “Effects of the number and position of the substituents on the in vitro photodynamic activities of glucosylated zinc(II) phthalocyanines” Org. Biomol. Chem. 2009, 7, 1583-1591.

47. Ermilov, E. A.*; Liu, J.-Y.; Ng, D. K. P.*; Röder, B. “Spectroscopic study of electron and energy transfer in novel silicon phthalocyanine-boron dipyrromethene triads” Phys. Chem. Chem. Phys. 2009, 11, 6430-6440.

48. Liu, J.-Y.; Yeung, H.-S.; Xu, W.; Li, X.; Ng, D. K. P.* “Highly Efficient Energy Transfer in Subphthalocyanine-BODIPY Conjugates” Org. Lett. 2008, 10(23), 5421-5424.

49. Liu, J.-Y.; Jiang, X.-J.; Fong, W.-P.; Ng, D. K. P.* “Highly photocytotoxic 1,4-dipegylated zinc(II) phthalocyanines. Effects of the chain length on the in vitro photodynamic activities” Org. Biomol. Chem. 2008, 6, 4560-4566.

50. Liu, J.-Y.; Jiang, X.-J.; Fong, W.-P.; Ng, D. K. P.* “Synthesis, Characterization, and in vitro Photodynamic Activities of Novel Amphiphilic Zinc(II) Phthalocyanines Bearing Oxyethylene-rich Substituents” Metal Based Drugs 2008, Article ID: 284691.

51. Lo, P.-C.; Chan, C. M. H.; Liu, J.-Y.; Fong, W.-P.; Ng, D. K.-P.* “Highly Photocytotoxic Glucosylated Silicon(IV) Phthalocyanines. Effects of Peripheral Chloro Substitution on the Photophysical and Photodynamic Properties” J. Med. Chem. 2007, 50(9), 2100-2107.

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