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刘见永

日期：2021-11-01 阅读次数：作者：来源：

	姓名：	刘见永
	性别：	男
	职称：	研究员（博导）
	学历：	博士
	职务：
	电话：	0591-22867105
	专业：	有机化学、药物化学、药理学、制药工程
	电子邮件：	liujianyong82@163.com
	研究方向：	有机共轭大环化合物的合成及性能研究

教育工作经历

2011 - 至今 betway唯一官方网站副研究员、研究员

2008－2010 香港中文大学化学系博士后

2005－2008 香港中文大学化学系博士

教学简介

承担本科生课程：《有机化学》《综合化学实验》《有机化学实验》

承担研究生课程：《实验室安全讲座》《有机化学研究方法与实验》

科研简介

研究兴趣：

氟硼二吡咯、酞菁类抗癌光敏药物的设计与药效研究；

有机染料分子荧光探针的设计及其在细胞、活体肿瘤中的成像研究；

染料敏化太阳能电池材料的设计及其光电转换性能研究；

酞菁和氟硼二吡咯的超分子化学。

社会兼职

中国抗癌协会光动力治疗专业委员会委员

中国化学会应用化学学科委员会卟啉与酞菁专业委员会秘书

受邀担任Journal of Medicinal Chemistry, European Journal of Medicinal Chemistry, Green Chemistry, Chemical Communications, Chemistry A European Journal, Organic Letters, RSC Advances, ChemMedChem, Current Medicinal Chemistry等期刊的通讯审稿人。

科研项目

1.国家自然科学基金：生物素介导靶向光动力治疗-化疗联用抗癌药物的合成及构效关系研究 (No.21401733)

2.国家自然科学基金：叶酸-酞菁共轭物抗癌光敏剂的合成及其靶向光动力活性 (No.21101028)

3.福建省科技厅重大项目：抗癌光敏剂福大赛因临床2期人体药代动力学研究（No. 2015Y0086）

4.福建省自然科学基金：光动力治疗-化疗联用前药的合成及协同抗肿瘤活性研究（No. 2020J01440）

5.福建省自然科学基金：Cu（I）催化“点击化学”合成靶向抗癌光敏剂 (No.2012J05021)

6.betway必威西汉姆联官网海外引进人才项目：功能配合物 (No.6022382)

7.betway必威西汉姆联官网科研启动项目：靶向抗癌光敏剂的研究 (No.600366)

8.betway必威西汉姆联官网科技发展基金：分子靶点抗癌光敏剂 (N0.2011-XY-6)

代表性论文

1. Wang, S.; Fu, Q.; Su, L.; Wu, Y.; Zhu, K.; Yang, D.-C.; Yang, X.-Z.; Weng, X.-L.; Liu, J.-Y.*; Song, J.* “Self-Reporting Molecular Prodrug for In Situ Quantitative Sensing of Drug Release by Ratiometric Photoacoustic Imaging”, ACS Sensors, 2023, 8, 4737-4746.

2. Yang, X.-Z.; Wen, L.-F.; Xu, G.; Lin, H.-H.; Wang, S.; Liu, J.-Y.* “Multifunctional organic nanomaterials with ultra-high photothermal conversion efficiency for photothermal therapy and inhibition of cancer metastasis”, Bioorganic Chemistry, 2023, 130, 106220.

3. Ke, Y.; Wei, D.; Lu, Z.; Cao, J.; Liu, J.-Y.; Fu, N. “A smart probe for multi-analyte signaling: Cascade detection of HSA mediated by N₂H₄”, Sensors and Actuators: B. Chemical, 2023, 395, 134456.

4. Yang, D.-C.; Wen, L.-F.; Du, L.; Luo, C.-M.; Lu, Z.-Y.; Liu, J.-Y.*; Lin, Z.* “A Hypoxia-Activated Prodrug Conjugated with a BODIPY-Based Photothermal Agent for Imaging-Guided Chemo-Photothermal Combination Therapy” ACS Applied Materials & Interfaces, 2022, 14, 40546-40558.

5. Yang, D.-C.; Yang, X.-Z.; Luo, C.-M.; Wen, L.-F.; Liu, J.-Y.*; Lin, Z.* “A promising strategy for synergistic cancer therapy by integrating a photosensitizer into a hypoxia-activated prodrug” Eur. J. Med. Chem., 2022, 243, 114749.

6. Zhang, H.-X.; Lin, H.-H.; Su, D.; Yang, D.-C.; Liu, J.-Y.* “Enzyme-Activated Multifunctional Prodrug Combining Site-Specific Chemotherapy with Light-Triggered Photodynamic Therapy”, Molecular Pharmaceutics 2022, 19, 630-641.

7. Hu, P.; Weng, X.-L.; Zhu, C.-H.; Yang, D.-C.; Liu, J.-Y.*; Chen, Z.*; Huang, M.* “Mitochondria-Targeting Boron Dipyrromethene Based Photosensitizers for Enhanced Photodynamic Therapy: Synthesis, Optical Properties, and in vitro Biological Activity”, ChemPlusChem, 2022, 87, e202200158.

8. Hu, P.; Xu, G.; Yang, D.-C.; Liu, J.-Y.*; Chen, Z.*; Huang, M.* “An advanced multifunctional prodrug combining photodynamic therapy with chemotherapy for highly efficient and precise tumor ablation”, Dyes and Pigments, 2022, 205, 110500.

9. Lin, H.-H.; Yang, X.-Z.; Yu, M.-Y.; Liu, J.-Y.* “A switchable phototherapeutic strategy based on a hypoxia-responsive photosensitizer for heterogeneous tumor ablation”, Dyes and Pigments, 2022, 201, 110217.

10. Lu, Z.; Xu, G.; Yang, X.; Liu, S.; Sun, Y.; Chen, L.; Liu, Q.; Liu, J.-Y.* “Dual-Activated Nano-Prodrug for Chemo-Photodynamic Combination Therapy of Breast Cancer” International Journal of Molecular Sciences, 2022, 23, 15656.

11. Xu, G.; Zhang, H.-X.; Li, X.-Q.; Yang, D.-C.; Liu, J.-Y.* “Red light triggered photodynamic-chemo combination therapy using a prodrug caged by photosensitizer”, Eur. J. Med. Chem., 2021, 215, 113251. DOI: 10.1016/j.ejmech.2021.113251.

12. Weng, X.-L.; Liu, J.-Y.* “Strategies for maximizing photothermal conversion efficiency based on organic dyes”, Drug Discov. Today, 2021, 26, 2045-2052. DOI: 10.1016/j.drudis.2021.03.009.

13. Yang, D.-C.; Wang, S.; Weng, X.-L.; Zhang, H.-X.; Liu, J.-Y.*; Lin, Z.* “Singlet Oxygen-Responsive Polymeric Nanomedicine for Light-Controlled Drug Release and Image-Guided Photodynamic−Chemo Combination Therapy”, ACS Appl. Mater. Interfaces, 2021, 13, 33905-33914.

14. Song, M.; Liu, G.; Liu, Y.; Cheng, Z.; Lin, H.; Liu, J.-Y.; Wu, Z.; Xue, J.; Hong, W.; Huang, M.; Li, J.; Xu, P. “Using porphyrins as albumin-binding molecules to enhance antitumorefficacies and reduce systemic toxicities of antimicrobial peptides”, Eur. J. Med. Chem., 2021, 217, 113382. DOI: 10.1016/j.ejmech.2021.113382.

15. Cao, J.-J.; Zhang, M.-S.; Li, X.-Q.; Yang, D.-C.; Xu, G.; Liu, J.-Y.* “A glutathione-responsive photosensitizer with fluorescence resonance energy transfer characteristics for imaging-guided targeting photodynamic therapy”. Eur. J. Med. Chem., 2020, 193, 112203. DOI:10.1016/j.ejmech.2020.112203.

16. Dai, T.; Ye, F.-R; Hu, P.; Pan, X.; Su, J.; Huang, Y.; Chen, J.; Zhang, L.; Wang, H.; Huang, M.; Liu, J.-Y.; Chen, X.; Chen, Z.*, “A strategy for enhanced tumor targeting of photodynamic therapy based on Escherichia coli-driven drug delivery system” Sci. China Mater., 2020, 64, 232-240.

17. Jiang, L.; Liu, Y.; Xu, X.; Su, D.; Zou, H.; Liu, J.-Y.; Yuan, C.; Huang, M. “Inhibition of the Citrus Canker Pathogen Using a Photosensitizer Assisted by Sunlight Irradiation”, Front Microbiol, 2020, 11, 571691.

18. Shi, W.-J.; Liu, J.-Y.; Lo, P.-C.; Ng, D. K.-P.* “Selective Detection of Hg²⁺ Ions with Boron Dipyrromethene-Based Fluorescent Probes Appended with a Bis(1,2,3-triazole)amino Receptor”, Chem. Asian. J., 2019, 14(7), 1059-1065.

19. Wang, Z.-W.; Su. D.; Li, X.-Q.; Cao, J.-J.; De-Chao Yang, Liu, J.-Y.* “A H₂O₂-Responsive Boron Dipyrromethene-Based Photosensitizer for Imaging-Guided Photodynamic Therapy”, Molecules 2019, 24, 32.

20. Chen, Y.; Liu, J.; Song, M.; Jiang, L.; Liu, L; Liu, Y.; Fu, G.; Xue, J.; Liu, J.-Y.*; Huang, M.*; Li, J*. “Insights into the binding mechanism of BODIPY-based photosensitizers to human serum albumin: A combined experimental and computational study”, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2018, 203, 158–165.

21. Lin, H.; Chen, J.; Zhang, Y.; Ullab, A.; Liu, J.-Y.; Lin, F.; Jiang, L.; Huang, M*. “Enhanced anti-microbial effect through cationization of a mono-triazatricyclodecane substituted asymmetric phthalocyanine”, J. Inorg. Biochem., 2018, 189, 192–198.

22. Zhang, F.-L.; Song, M.-R.; Yuan, G.-K.; Ye, H.-N.; Tian, Y.; Huang, M.-D.; Xue, J.-P.; Zhang, Z.-H.*; Liu, J.-Y.* “A Molecular Combo of Zinc(II) Phthalocyanine and Tamoxifen Derivative for Dual Targeting Photodynamic Therapy and Hormone Therapy” J. Med. Chem., 2017, 60, 6693-6703.

23. Liu, J.-Y.*; Hou, X.-N.; Tian, Y.; Jiang, L.*; Deng, S.; Röder, B.; Ermilov, E. A.* “Photoinduced energy and charge transfer in a bis(triphenylamine)–BODIPY–C₆₀ artificial photosynthetic system”, RSC Advances, 2016, 6, 57293-57305.

24. Liu, J.-Y.; Li, J.; Yuan, X.; Wang, W.-M.; Xue, J.-P.* “In vitro photodynamic activities of zinc(II) phthalocyanines substituted with pyridine moieties”, Photodiagnosis and Photodynamic Therapy, 2016, 13, 341-343.

25. Chen, J.; Ye, H.; Zhang, M.; Li, J.; Liu, J.-Y.*; Xue, J.-P.* “Erlotinib Analogue-substituted Zinc(II) Phthalocyanines for Small Molecular Target-based Photodynamic Cancer Therapy”, Chin. J. Chem., 2016, 34, 983-988.

26. Ermilov, E. A. *; Liu, J.-Y.; Menting, R.; Huang, Y.-S.; Röder, B.; Ng, D. K. P.* “An artificial photosynthetic model based on a molecular triad of boron dipyrromethene and phthalocyanine” Phys. Chem. Chem. Phys., 2016, 18, 10964-10975.

27. Zhang, F.-L.; Huang, Q.; Liu, J.-Y.; Huang, M.-D.; Xue, J.-P.* “Molecular-Target-Based Anticancer Photosensitizer: Synthesis and in vitro Photodynamic Activity of Erlotinib–Zinc(II)Phthalocyanine Conjugates” ChemMedChem, 2015, 10(2), 312-320.

28. Ermilov, E. A.*; Schlak, M.; Steffen, R.; Liu, X.-Q.; Liu, J.-Y.; Röder, B. “Energy transfer properties of a novel boron dipyrromethene–perylenediimide donor–acceptor dyad” RSC Adv., 2015, 5, 67141-67148.

29. Zhou, X.-Q.; Meng, L.-B.; Huang, Q.; Li, J.; Zheng, K.; Zhang, F.-L.; Liu, J.-Y.; Xue, J.-P.* “Synthesis and in vitro Anticancer Activity of Zinc(II) Phthalocyanines Conjugated with Coumarin Derivatives for Dual Photodynamic and Chemotherapy” ChemMedChem, 2015, 10, 304-311.

30. Lin, J.; Zhu, C.; Liu, X.; Chen, B.; Zhang, Y.; Xue, J.; Liu, J.-Y.* “A Highly Selective and turn-on fluorescence probe for Fe³⁺ ion based on perylene tetracarboxylic diimide” Chin. J. Chem., 2014, 32, 1116-1120.

31. Jia, X.; Yue, F.; Chen, X.; Pan, H.-B.; Liu, W.-G.*; Liu, J.-Y.* “One-pot controlled synthesis of single-crystal a-Fe₂O₃ hollow nanostructure and its gas sensing properties” RSC Adv., 2014, 4, 42899-42904.

32. Chen, Z.; Xu, P.; Chen, J.; Chen, H.; Hu, P.; Chen, X.; Lin, L.; Huang, Y.; Zheng, K.; Zhou, S.; Li, R.; Chen, S.; Liu, J.-Y.; Xue, J.; Huang, M. “Zinc phthalocyanine conjugated with the amino-terminal fragment of urokinase for tumor-targeting photodynamic therapy” Acta Biomaterialia, 2014, 10(10), 4257-4268.

33. Liu, J.-Y.; Huang, Y.-S.; Menting, R.; Röder, B.; Ermilov, E. A.; Ng, D. K. P.* “A boron dipyrromethene-phthalocyanine pentad as an artificial photosynthetic model” Chem. Commun. 2013, 49, 2998-3000.

34. Liu, J.-Y.; Ermilov, E. A.; Röder, B.; Ng, D. K. P.* “A light-harvesting porphyrin-boron dipyrromethene conjugate” J. Porphyrins Phthalocyanines 2013, 17, 831-835.

35. Menting, R.; Liu, J.-Y.; Huang, Y.-S.; Ng, D. K. P.; Röder, B.; Ermilov, E. A.* “Photoinduced energy and charge transfer in a p-phenylene-linked dyad of boron dipyrromethene and monostyryl boron dipyrromethene” Phys. Chem. Chem. Phys. 2013, 15, 6912-6919.

36. Zhang, F.-L.; Huang, Q.; Zheng, K.; Li, J.; Liu, J.-Y.*; Xue, J.-P.* “A novel strategy for targeting photodynamic therapy. Molecular combo of photodynamic agent zinc(II) phthalocyanine and small molecule target-based anticancer drug erlotinib” Chem. Commun. 2013, 49, 9570-9572.

37. Jia, X.; Yang, F.-F.; Li, J.; Liu, J.-Y.; Xue, J.-P.* “Synthesis and in Vitro Photodynamic Activity of Oligomeric Ethylene Glycol−Quinoline Substituted Zinc(II) Phthalocyanine Derivatives” J. Med. Chem. 2013, 56, 5797-5805.

38. He, H.; Liu, J.-Y.; and Ng, D. K. P.* “A Phthalocyanine-Based Fluorescent Sensor for Zn²⁺ Ion”, J. Porphyrins Phthalocyanines” 2013, 17, 99-103.

39. Liu, J.-Y.; El-Khouly, M. E.; Fukuzumi, S.; Ng, D. K. P.* “Photoinduced Electron Transfer in a Ferrocene-Distyryl BODIPY Dyad and a Ferrocene-Distyryl BODIPY-C₆₀ Triad” ChemPhysChem, 2012, 13, 2030-2036.

40. Shi, W.-J.; Liu, J.-Y.; Ng, D. K. P.* “A Highly Selective Colorimetric and Fluorescent Probe for Cu²⁺ and Hg²⁺ Ions Based on a Distyryl BODIPY with Two Bis(1,2,3-triazole)amino Receptors” Chem. Asian. J. 2012, 7(1), 196-200.

41. Liu, J.-Y.; El-Khouly, M. E.; Fukuzumi, S.*; Ng, D. K. P.* “Mimicking the Photosynthetic Antenna-Reaction Center Complexes with a (Boron Dipyrromethene)₃-Porphyrin-C₆₀ Pentad” Chem. Eur. J. 2011, 17, 1605-1613.

42. Liu, J.-Y.; El-Khouly, M. E.; Fukuzumi, S.; Ng, D. K. P.* “Photoinduced Electron Transfer in a Distyryl BODIPY-Fullerene Dyad” Chem. Asian. J. 2011, 6, 174-179.

43. Liu, J.-Y.; Lo, P.-C.; Ng, D. K. P.* “Phthalocyanine-Containing Supramolecular Arrays” Struct. Bond. 2010, 135, 169-210.

44. Liu, J.-Y.; Ermilov, E. A.; Röder, B.; Ng, D. K. P.* “Switching the photo-induced energy and electron-transfer processes in BODIPY-phthalocyanine conjugates” Chem. Commun. 2009, 45, 1517-1519.

45. Liu, J.-Y.; Lo, P.-C.; Jiang, X.-J.; Fong, W.-P.; Ng, D. K. P.* “Synthesis and in vitro photodynamic activities of di-a-substituted zinc(II) phthalocyanine derivatives” Dalton Trans. 2009, 38, 4129-4135.

46. Liu, J.-Y.; Lo, P.-C.; Fong, W.-P.; Ng, D. K. P.* “Effects of the number and position of the substituents on the in vitro photodynamic activities of glucosylated zinc(II) phthalocyanines” Org. Biomol. Chem. 2009, 7, 1583-1591.

47. Ermilov, E. A.*; Liu, J.-Y.; Ng, D. K. P.*; Röder, B. “Spectroscopic study of electron and energy transfer in novel silicon phthalocyanine-boron dipyrromethene triads” Phys. Chem. Chem. Phys. 2009, 11, 6430-6440.

48. Liu, J.-Y.; Yeung, H.-S.; Xu, W.; Li, X.; Ng, D. K. P.* “Highly Efficient Energy Transfer in Subphthalocyanine-BODIPY Conjugates” Org. Lett. 2008, 10(23), 5421-5424.

49. Liu, J.-Y.; Jiang, X.-J.; Fong, W.-P.; Ng, D. K. P.* “Highly photocytotoxic 1,4-dipegylated zinc(II) phthalocyanines. Effects of the chain length on the in vitro photodynamic activities” Org. Biomol. Chem. 2008, 6, 4560-4566.

50. Liu, J.-Y.; Jiang, X.-J.; Fong, W.-P.; Ng, D. K. P.* “Synthesis, Characterization, and in vitro Photodynamic Activities of Novel Amphiphilic Zinc(II) Phthalocyanines Bearing Oxyethylene-rich Substituents” Metal Based Drugs 2008, Article ID: 284691.

51. Lo, P.-C.; Chan, C. M. H.; Liu, J.-Y.; Fong, W.-P.; Ng, D. K.-P.* “Highly Photocytotoxic Glucosylated Silicon(IV) Phthalocyanines. Effects of Peripheral Chloro Substitution on the Photophysical and Photodynamic Properties” J. Med. Chem. 2007, 50(9), 2100-2107.

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